Synthesis and Biological Evaluation of Dibenz[b, f][1, 5]Oxazocine Derivatives for Agonist Activity at k-opioid Receptor

Mitra, Sudipta and Banerjee, Tuhin Suvro and Hota, Sandip K and Bhattacharya, Debleena and Das, Sumantra and Chattopadhyay, Partha (2011) Synthesis and Biological Evaluation of Dibenz[b, f][1, 5]Oxazocine Derivatives for Agonist Activity at k-opioid Receptor. European Journal of Medicinal Chemistry. pp. 1-8.

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    Abstract

    A short and high yield synthetic route to dibenz[b, f][1, 5]oxazocines has been developed using Pd catalyzed intramolecular cycloamination reaction. Receptor binding assay using [125I]-dynorphin demonstrated that one of the derivative, 5b showed selective k-opioidergic property.

    Item Type: Article
    URI: http://www.eprints.iicb.res.in/id/eprint/1071
    Subjects: Cell Biology & Physiology
    Chemistry
    Divisions: Indian Institute of Chemical Biology
    Depositing User: Mr Santanu Sadhukhan
    Date Deposited: 28 Dec 2011 12:39
    Last Modified: 28 Dec 2011 12:39
    Official URL: http://dx.doi.org/10.1016/j.ejmech.2011.02.024
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