Evidence of Direct Interactions Between the CC-Chemokines CCL3, CCL4 and CCL5 and Leishmania Promastigotes

Roychoudhury, Kaushik and Dasgupta, Biplab and Sen, Pradip and Laskay, Tam'as and Solbach, Werner and De, Tripti and Roy, Syamal (2006) Evidence of Direct Interactions Between the CC-Chemokines CCL3, CCL4 and CCL5 and Leishmania Promastigotes. Molecular & Biochemical Parasitology, 150 (2). pp. 374-377.

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    Abstract

    Parasites of the genus Leishmania are very successful parasites, possessing multiple host evasive machineries and unique molecules that aid in their survival. It is presumed that a freshly inoculated parasite needs to survive in the hostile extracellular environment for several hours before it is internalized by a macrophage [1,2]. How the parasite survives within this extracellular environment and find their way to a macrophage are matters of great interest and enigma to clinicians and biologists alike. Chemotactic molecules secreted by the parasite, that are to this day uncharacterized, can home certain host cells and probably play a major role in the process of inviting host cells to the site of infection [3]. Host derived chemotactic molecules, especially chemokines also play an important role in the homing of cells to the site of infection [4]. What is not clear is whether these host derived chemotactic factors can also be sensed and utilized by the parasites.

    Item Type: Article
    URI: http://www.eprints.iicb.res.in/id/eprint/1089
    Subjects: Infectious Diseases and Immunology
    Divisions: Indian Institute of Chemical Biology
    Depositing User: Mr Santanu Sadhukhan
    Date Deposited: 28 Dec 2011 17:13
    Last Modified: 15 Jan 2013 12:13
    Official URL: http://dx.doi.org/10.1016/j.molbiopara.2006.08.009
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