RNA Specific Molecules: Cytotoxic Plant Alkaloid Palmatine Binds Strongly to Poly(A)

Giri, Prabal and Hossain, Maidul and Kumar, G Suresh (2006) RNA Specific Molecules: Cytotoxic Plant Alkaloid Palmatine Binds Strongly to Poly(A). Bioorganic & Medicinal Chemistry Letters, 16 (9). pp. 2364-2368.

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    Abstract

    Abstract—The cytotoxic plant alkaloid palmatine was found to bind strongly by partial intercalation to single stranded poly(A) structure with binding affinity (Ka) of (8.36 ± 0.26) · 105 M�1. The binding of palmatine was characterized to be exothermic and enthalpy driven with one palmatine for every two adenine residues. On the other hand, the binding to the double stranded poly(A) has been found to be significantly weak. This study identifies poly(A) as a potential bio-target for the alkaloid palmatine and its use as a lead compound in antitumor drug screening.

    Item Type: Article
    URI: http://www.eprints.iicb.res.in/id/eprint/1116
    Subjects: Chemistry
    Divisions: Indian Institute of Chemical Biology
    Depositing User: Mr Santanu Sadhukhan
    Date Deposited: 29 Dec 2011 12:05
    Last Modified: 03 Feb 2012 12:13
    Official URL: http://dx.doi.org/10.1016/j.bmcl.2006.01.124
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