Daboia Russellii and Naja Kaouthia Venom Neutralization by Lupeol Acetate Isolated From the Root Extract of Indian Sarsaparilla Hemidesmus Indicus R.Br.

Chatterjee, Ipshita and Chakravarty, A K and Gomes, Aparna (2006) Daboia Russellii and Naja Kaouthia Venom Neutralization by Lupeol Acetate Isolated From the Root Extract of Indian Sarsaparilla Hemidesmus Indicus R.Br. Journal of Ethnopharmacology, 106 (1). pp. 38-43.

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    Abstract

    The present study reports the isolation and purification of lupeol acetate from the methanolic root extract of Indian medicinal plant Hemidesmus indicus (L.) R.Br. (family: Asclepiadaceae) which could neutralize venom induced action of Daboia russellii and Naja kaouthia on experimental animals. Lupeol acetate could significantly neutralize lethality, haemorrhage, defibrinogenation, edema, PLA2 activity induced by Daboia russellii venom. It also neutralized Naja kaouthia venom induced lethality, cardiotoxicity, neurotoxicity and respiratory changes in experimental animals. Lupeol acetate potentiated the protection by snake venom antiserum action against Daboia russellii venom induced lethality in male albino mice. Venom induced changes in lipid peroxidation and super oxide dismutase activity was antagonized by lupeol acetate. Snake venom neutralization by lupeol acetate and its possible mechanism of action has been discussed.

    Item Type: Article
    URI: http://www.eprints.iicb.res.in/id/eprint/1118
    Subjects: Drug Development/Diagnostics & Biotechnology
    Divisions: Indian Institute of Chemical Biology
    Depositing User: Mr Santanu Sadhukhan
    Date Deposited: 29 Dec 2011 12:10
    Last Modified: 29 Dec 2011 12:10
    Official URL: http://dx.doi.org/10.1016/j.jep.2005.11.031
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