Anticlastogenic eVects of Black Tea Polyphenols TheaXavins and Thearubigins in Human Lymphocytes in Vitro

Halder, Babli and Pramanick, Swapan and Mukhopadhyay, Sibabrata and Giri, Ashok K (2006) Anticlastogenic eVects of Black Tea Polyphenols TheaXavins and Thearubigins in Human Lymphocytes in Vitro. Toxicology in Vitro, 20. pp. 608-613.

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    Abstract

    Black tea accounts for nearly 80% of total World tea production. It contains dimeric Xavanols and polymeric polyphenols known as theaXavins (TF) and thearubigins (TR). TR is exclusively present in black tea. On the basis of our previous potent antimutagenic and anticlastogenic eVects of TF and TR in vitro in bacterial system and in vivo in mouse bone marrow cells, we have decided to extend our study in human cells in vitro. This study investigated the anticlastogenic eVects of black tea polyphenols TF and TR as measured by chromosomal aberrations (CA) and micronuclei formation (MN) against two known mutagens/carcinogens i.e. benzo[a]pyerne (B[a]P) and aXatoxin B1(AFB1) with S9 activation. A signiWcant decrease in both CA and MN were observed in the human lymphocyte cultures treated with either TF or TR pretreated with either B[a]P or AFB1 (250, 500, 1000 �g/ml) when compared with B[a]P or AFB1 treated cultures alone. TF shows more protective eVects than TR in this in vitro system. These results indicate that both TF and TR have signiWcant anticlastogenic eVects in vitro in human lymphocytes.

    Item Type: Article
    URI: http://www.eprints.iicb.res.in/id/eprint/1196
    Subjects: Chemistry
    Divisions: Indian Institute of Chemical Biology
    Depositing User: Mr Shyamal Nath
    Date Deposited: 30 Dec 2011 13:27
    Last Modified: 03 Feb 2012 12:17
    Official URL: http://dx.doi.org/10.1016/j.tiv.2005.10.010
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