Synthesis of Novel Heme-Interacting Acridone Derivatives to Prevent Free Heme-Mediated Protein Oxidation and Degradation.

Pal, Chinmay and Kundu, Milan Kumar and Bandyopadhyay, Uday and Adhikari, Susanta (2011) Synthesis of Novel Heme-Interacting Acridone Derivatives to Prevent Free Heme-Mediated Protein Oxidation and Degradation. Bioorganic & Medicinal Chemistry Letters, 21 (12). pp. 3563-3567.

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    Abstract

    Heme is an important prosthetic molecule for various hemoproteins and serves important function in living aerobic organisms. But degradation of hemoprotein, for example, hemoglobin during different pathological conditions leads to the release of heme, which is very toxic as it induces oxidative stress and inflammation due to its pro-oxidant nature. Thus, synthesis of compound that will detoxify free heme by interacting with it would be fruitful for the management of heme-induced pathogenesis. Here, we report the synthesis of a novel natural product arborinine and some other acridone derivatives, which interact with free heme. These acridones in vitro block heme-mediated protein oxidation and degradation, markers for heme-induced oxidative stress

    Item Type: Article
    URI: http://www.eprints.iicb.res.in/id/eprint/1235
    Subjects: Infectious Diseases and Immunology
    Divisions: Indian Institute of Chemical Biology
    Depositing User: Ms Sutapa Ganguly
    Date Deposited: 16 Jan 2012 15:02
    Last Modified: 16 Jan 2012 15:02
    Official URL: http://dx.doi.org/10.1016/j.bmcl.2011.04.127
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