AmberliteeIRA-402 (OH) Ion Exchange Resin Mediated Synthesis of Indolizines, Pyrrolo [1,2-a] Quinolines and Isoquinolines: Antibacterial and Antifungal evaluation of the products

Hazra, Abhijit and Mondal, Shyamal and Maity, Arindam and Naskar, Subhendu and Saha, Pritam and Paira, Rupankar and Sahu, Krishnendu B and Paira, Priyankar and Ghosh, Soma and Sinha, Chandrima and Samanta, Amalesh and Banerjee, Sukdeb and Mondal, Nirup B (2011) AmberliteeIRA-402 (OH) Ion Exchange Resin Mediated Synthesis of Indolizines, Pyrrolo [1,2-a] Quinolines and Isoquinolines: Antibacterial and Antifungal evaluation of the products. European Journal of Medicinal Chemistry, 46 (6). pp. 2132-2140.

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Abstract

A number of indolizines and pyrrolo[1,2-a]quinolines/isoquinolines were prepared from phenacyl pyridinium, quinolinium and isoquinolinium salts derived fromthe reaction of the heterocycles with 2-bromo acetophenone with alkynes and alkenes using amberliteeIRA-402 (OH) ion exchange resin as the base. Antibacterial and antifungal studies were carried out against thirteen bacterial and four fungal strains, which revealed that three derivatives (4a, 4b, 7a) out of fifteen are effective against all the thirteen strains and one derivative, 10, showed dual antibactericidal and antifungal efficacy

Item Type: Article
URI: http://www.eprints.iicb.res.in/id/eprint/1256
Subjects: Chemistry
Divisions: Indian Institute of Chemical Biology
Depositing User: Ms Sutapa Ganguly
Date Deposited: 18 Jan 2012 14:36
Last Modified: 18 Jan 2012 15:35
Official URL: http://dx.doi.org/10.1016/j.ejmech.2011.02.066
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