Synthesis of Chiral Benzoxa(thia)zepine and Pyridoxazepine Derivatives Using Palladium-Catalyzed Intramolecular Aryl Amination Reaction.

Das Adhikary, Nirmal and Chattopadhyay, Partha (2011) Synthesis of Chiral Benzoxa(thia)zepine and Pyridoxazepine Derivatives Using Palladium-Catalyzed Intramolecular Aryl Amination Reaction. European Journal of Organic Chemistry, 36. 7346-7354 . ISSN 1434-193X

[img]

PDF
Restricted to IICB Scientists only

Download (473Kb) | Request a copy

    Abstract

    A palladium-catalyzed method employing different bulky biaryl phosphanes as ligands has been developed for the intramolecular amination of aryl bromides and iodides. A variety of aryl halide substrates have been aminated through the intramolecular pathway in good yield using different sugar-derived amines to give furo-benzoxa(thia)zepine and pyridoxazepine derivatives. The method is capable of furnishing chiral, enantiopure benzoxa(thia)zepines and pyridoxazepines of significant biological importance.

    Item Type: Article
    URI: http://www.eprints.iicb.res.in/id/eprint/1258
    Subjects: Chemistry
    Divisions: Indian Institute of Chemical Biology
    Depositing User: Ms Sutapa Ganguly
    Date Deposited: 18 Jan 2012 16:02
    Last Modified: 18 Jan 2012 16:02
    Official URL: http://dx.doi.org/10.1002/ejoc.201101174
    Links:

    Actions (login required)

    View Item