Anticholinesterase Activity of Standardized Extract of Illicium Verum Hook. F. Fruits

Bhadra, Santanu and Mukherjee, Pulok K and Kumar, N Satheesh and Bandyopadhyay, Arun (2011) Anticholinesterase Activity of Standardized Extract of Illicium Verum Hook. F. Fruits. Fitoterapia, 82 (3). pp. 342-346.

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    Abstract

    Illicium verum is a well known spice in traditional Indian system for its therapeutic potential. The present study was aimed to evaluate the acetylcholinesterase (AChE) and butyrylcholinesterase inhibitory (BChE) activity of standardized extracts of I. verum and its oil. Present study confirmed that anethole contributed to the anticholinesterase activity of I. verum, with more specificity towards AChE. IC50 for AChE and BChE inhibitory activity of anetholewas 39.89±0.32 μg/mL and 75.35±1.47 μg/mL, whereas for the oil, 36.00±0.44 μg/mL and 70.65±0.96 μg/mL respectively. Therefore I. verum can be a good lead as anti-cholinesterase agent from natural resources.

    Item Type: Article
    URI: http://www.eprints.iicb.res.in/id/eprint/1261
    Subjects: Cell Biology & Physiology
    Divisions: Indian Institute of Chemical Biology
    Depositing User: Ms Sutapa Ganguly
    Date Deposited: 19 Jan 2012 11:59
    Last Modified: 19 Jan 2012 12:00
    Official URL: http://dx.doi.org/10.1016/j.fitote.2010.11.003
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