Synthesis and Evaluation of Technetium-99m (i) Tricarbonyl and Technetium-99m (v) oxo Chelates of Various amino, Carboxy and Thiol Based Ligand Systems: Utilization of this approach Towards the Development of Site Specific Radiopharmaceuticals.

Halder, Kamal Krishna (2011) Synthesis and Evaluation of Technetium-99m (i) Tricarbonyl and Technetium-99m (v) oxo Chelates of Various amino, Carboxy and Thiol Based Ligand Systems: Utilization of this approach Towards the Development of Site Specific Radiopharmaceuticals. PhD thesis, Jadavpur University.

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Chatterjee Debnath , Mita

Abstract

Technetium-99m (99mTc) based radiopharmaceuticals have established themselves as a very important class of compounds in the diagnosis of various organ malfunction in computerized g-camera imaging. These types of radiopharmaceuticals are produced in many cases by chelating 99mTc with organic compounds having multifunctional electron rich groups which through coordination establish chemical bond with the metal. The complexes thus formed accommodate technetium in different oxidation states.The most stable and readily accessible oxidation states are often characterized by chemically robust core structures which may be exploited as platforms for the development of radiopharmaceutical reagents. The most extensively developed core structure is {Tc(V)O}3+, particularly with tetradentate ligands of the NxS(4-x) type. Past research has focused primarily on attachment of the bifunctional chelators for complexation of the {Tc(V)O}3+ core into small tripeptides and tetra-peptides. This has been accomplished predominantly using N3S and N4 ligands. Other structural subunits which have attracted attention include the {TcN}2+, {TcO2}+, and technetium 6-hydrazinonicotinic acid {Tc(HYNIC)x}3+ (where x = 1 or 2) cores. More recently, the Tc(I) core, technetium tricarbonyl {Tc(CO)3}+ has been shown to provide an ideal geometry for the labeling of chelators of the {Tc(CO)3}+ core with high specific activity.

Item Type: Thesis (PhD)
URI: http://www.eprints.iicb.res.in/id/eprint/1462
Subjects: Infectious Diseases and Immunology
Divisions: Indian Institute of Chemical Biology
Depositing User: Ms Sutapa Ganguly
Date Deposited: 21 Jun 2012 16:02
Last Modified: 29 Jun 2012 12:42
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