Antioxidant and antibacterial activities of bark extracts from Commiphora berryi and Commiphora caudata

Kumari, Ramesh and Meyyappan, Arumugam and Nandi, Debkumar and Agrawal, Bikram Keshari and Acharya Chowdhury, Avik and Selvamani, Palanisamy and Latha, Subbaiah and Giri, V S and Mukherjee, Joydeep and Bandyopadhyay, Santu and Jaisankar , P (2011) Antioxidant and antibacterial activities of bark extracts from Commiphora berryi and Commiphora caudata. Natural Product Research, 25 (15). pp. 1454-1462. ISSN 1478-6419

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    Abstract

    This study investigates the in vitro antioxidant and antimicrobial activities of eight extracts obtained from the dried barks of Commiphora berryi and Commiphora caudata (Burseraceae). The radical scavenging activity was assessed by 1,1-diphenyl-2-picryl hydrazyl (DPPH) and nitric oxide assays. The methanolic extracts of C. berryi and C. caudata showed significant DPPH radical scavenging activity, with IC50 values of 26.92 and 21.16 mgmL�1, respectively, and low radical scavenging activity against the nitric oxide assay. The antimicrobial activity of the plants was tested against the Gram-positive and Gram-negative bacteria. The ethyl acetate, chloroform and petroleum ether extracts of C. berryi showed good antibacterial activity against Pseudomonas aeruginosa, with a minimum inhibitory concentration (MIC) of 0.26 mgmL�1, whereas the ethyl acetate and methanol extracts of C. caudata showed moderate antimicrobial activity with an MIC of more than 2.0 mgmL�1 against P. aeruginosa compared to the petroleum ether and chloroform extracts, which showed an MIC of 1.1 mgmL�1. The methanolic extracts of C. berryi and C. caudata also showed moderate cytotoxic activity against a human mammary carcinoma cell line (MCF-7), with values IC50 of 82.6 and 88.4 mgmL�1, respectively

    Item Type: Article
    URI: http://www.eprints.iicb.res.in/id/eprint/1632
    Subjects: Chemistry
    Infectious Diseases and Immunology
    Divisions: Indian Institute of Chemical Biology
    Depositing User: Ms Sutapa Ganguly
    Date Deposited: 14 Sep 2012 14:59
    Last Modified: 14 Sep 2012 14:59
    Official URL: http://dx.doi.org/10.1080/14786411003752052
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