Hepatoprotective Activity of the Edible snail (Bellamia bengalensis) Flesh Extract in Carbon Tetrachloride Induced Hepatotoxicity in Rats

Gomes, Antony and Alam, Mohammed Aftab and Datta, Poulami and Bhattacharya, Shamik and Gomes, Aparna (2011) Hepatoprotective Activity of the Edible snail (Bellamia bengalensis) Flesh Extract in Carbon Tetrachloride Induced Hepatotoxicity in Rats. Journal of Ethnopharmacology, 138. pp. 228-232.

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    Abstract

    Ethnopharmacological relevance: In the folk-traditional medicine, snails were used to purify blood, boost immune system, prevent conjunctivitis and to treat liver problems. Objectives: To evaluate the hepatoprotective activity of the edible snail (Bellamia bengalensis) flesh extract in male Wistar rats treated with carbon tetrachloride as an hepatotoxicant. Materials and methods: Live adult Bellamia bengalensis was collected commercially from the Kolkata market. Aqueous flesh extract (BBE) was prepared in 0.9% saline and expressed in terms of wet weight basis. The aqueous flesh extract was administered orally (1, 2 g kg−1 day−1) to male rats for 12 days. Liv52 was used as positive control. 24 h after administration of extract, the rats were given a single oral dose of CCl4 (1.25 ml kg−1), except vehicle control rats. After 24 h of CCl4 administration, all the animals were sacrificed to collect the blood and liver tissue. Results: BBE (1 and 2 g kg−1 day−1, p.o. × 12 days) significantly prevented CCl4 induced elevation of SGOT, SGPT, �GT, ACP, ALP, bilirubin, LDH and CCl4 induced decrease in total protein, triglyceride level in male Wistar rats. BBE treated rat liver anti-oxidant parameters (LPO, SOD, GSH, CAT, GPx) were significantly antagonized for the pro-oxidant effect of CCl4. Histopathological studies also supported the protective effect of BBE. Conclusion: This study validated the folk and traditional use of snail in liver disorder through CCl4-induced rat experimental model

    Item Type: Article
    URI: http://www.eprints.iicb.res.in/id/eprint/1678
    Subjects: Drug Development/Diagnostics & Biotechnology
    Divisions: Indian Institute of Chemical Biology
    Depositing User: Ms Sutapa Ganguly
    Date Deposited: 13 Dec 2012 14:48
    Last Modified: 13 Dec 2012 14:48
    Official URL: http://dx.doi.org/10.1016/j.jep.2011.09.009
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