Development of Elegant Methods for the Synthesis of Novel Heterocycles

Sasmal, Anup Kumar (2011) Development of Elegant Methods for the Synthesis of Novel Heterocycles. PhD thesis, Jadavpur University.


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    Chowdhury, Chinmay


    Heterocyclic compounds have attracted much pharmacological and synthetic interest as they have been found in many biologically important scaffolds. Therefore, development of efficient and elegant methodologies for the synthesis of novel fused heterocycles of biological significance is a challenging task in organic chemistry. The research work embodied in this thesis describes efficient and elegant protocols for the synthesis of triazole fused benzoxazines, triazole fused benzodiazepines/benzodiazocines and pyrazole fused benzodiazepines applying palladium-copper catalyzed reactions and 1,3- dipolar cycloaddition. The work has been presented in three Chapters.Describes the efficient synthesis of 3-aryl substituted [1,2,3]triazolo[5,1- c][1,4]benzoxazines using palladium and copper catalysts in one-pot through Sonogashira coupling followed by azide-alkyne cycloaddition.Describes a facile and expedient general synthesis of novel tricyclic scaffolds 3-aryl substituted [1,2,3]triazolo[1,5-a][1,4]benzodiazepin-6-ones and[1,2,3]triazolo[1,5-a][1,5]benzodiazocin-7-ones through Sonogashira coupling followed by in situ diazotization, azidation and azide-alkyne cycloaddition reactions.

    Item Type: Thesis (PhD)
    Subjects: Chemistry
    Divisions: Indian Institute of Chemical Biology
    Depositing User: Mr Santanu Sadhukhan
    Date Deposited: 20 Dec 2012 15:59
    Last Modified: 20 Dec 2012 15:59

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