Studies on Alcohol Induced Gastric and Liver Damage: Role of Matrix Metalloproteinases

Mishra, Amartya (2011) Studies on Alcohol Induced Gastric and Liver Damage: Role of Matrix Metalloproteinases. PhD thesis, Jadavpur University.


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    Swarnakar, Snehasikta


    Alcohol, specifically ethanol is the most socially accepted addictive drug, which can have life-threatening health hazards (Grant et al., 1988; McGinnis and Foege, 1993; Rehm et al., 2009). Its pleasures are very widely acknowledged and form a bond of community for the majority of adults in Western countries. Alcoholic beverages are a standard "lubricant" (anxiety-reliever) at social gatherings (Guo and Ren, 2010).Yet, some people are concerned about consuming a substance, which causes physical and mental discoordination (Babor et al., 2003). Interestingly, highest diseases load attributed to alcoholism in former socialist countries of Eastern Europe and in Latin America (Fig. 1). Moderate alcohol drinkers are at lower risk of heart disease than either abstainers or heavy imbibers (Marmot, 2001; Pearson, 2004a). Developed countries have the next biggest problem especially about the binge drinking among the young. In most developing counties, alcohol consumption is still relatively low but it is climbing steeply, particularly in Asia, driven by economic growth and aggressive marketing (Pearson, 2004a). Many people assume that a tipple or two a day is a tonic, but researchers believe this assumption is based chiefly on misleading media reports and wishful thinking (Bobak et al., 2000; Marmot, 2001).National Institute on Alcohol Abuse and Alcoholism (NIAAA) in the United States reviewed scientific literature showing the relative risks and benefits of drinking in moderation (Gunzerath et al., 2004). The review weighs these benefits against alcohol’s myriad detrimental effects, such as the increased risk of injury, breast cancer, liver diseases and other conditions (Gunzerath et al., 2004; Pearson, 2004b).When both benefits and risks are factored into the equation, the reviewers conclude, people still seem to reduce their overall health risks by having one or two alcoholic drinks a day.

    Item Type: Thesis (PhD)
    Subjects: Drug Development/Diagnostics & Biotechnology
    Divisions: Indian Institute of Chemical Biology
    Depositing User: Mr Santanu Sadhukhan
    Date Deposited: 24 Dec 2012 12:52
    Last Modified: 24 Dec 2012 12:52

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