Chromatin Remodeling Protein SMAR1 Is a Critical Regulator of T Helper Cell Differentiation and Inflammatory Diseases

Mirlekar, Bhalchandra and Gautam, Dipendra and Chattopadhyay, Samit (2017) Chromatin Remodeling Protein SMAR1 Is a Critical Regulator of T Helper Cell Differentiation and Inflammatory Diseases. Frontiers in Immunology, 8 (72). 01p.-11p..

[img]
Preview

PDF

Download (2053Kb) | Preview

    Abstract

    T cell differentiation from naïve T cells to specialized effector subsets of mature cells is determined by the iterative action of transcription factors. At each stage of specificT cell lineage differentiation, transcription factor interacts not only with nuclear proteins such as histone and histone modifiers but also with other factors that are bound to the chromatin and play a critical role in gene expression. In this review, we focus on one of such nuclear protein known as tumor suppressor and scaffold matrix attachment region-binding protein 1 (SMAR1) in CD4+ T cell differentiation. SMAR1 facilitates Th1 differentiation by negatively regulating T-bet expression via recruiting HDAC1–SMRT complex to its gene promoter. In contrast, regulatory T (Treg) cell functions are dependent on inhibition of Th17-specific genes mainly IL-17 and STAT3 by SMAR1. Here, we discussed a critical role of chromatin remodeling protein SMAR1 in maintaining a fine-tuned balance between effector CD4+ T cells and Treg cells by influencing the transcription factors during allergic and autoimmune inflammatory diseases.

    Item Type: Article
    URI: http://www.eprints.iicb.res.in/id/eprint/2612
    Subjects: Cancer Biology and Inflammatory Disorder Division
    Divisions: Indian Institute of Chemical Biology
    Depositing User: Ms Sutapa Ganguly
    Date Deposited: 20 Mar 2017 10:40
    Last Modified: 20 Mar 2017 15:59
    Official URL: http://dx.doi.org/10.3389/fimmu.2017.00072
    Links:

    Actions (login required)

    View Item