Exploring The Genome And Proteome Landscapes Of The Genus Bacillus In Quest Of Lineage And Niche Specific Traits Through In Silico Analysis

Goswami, Aranyak (2017) Exploring The Genome And Proteome Landscapes Of The Genus Bacillus In Quest Of Lineage And Niche Specific Traits Through In Silico Analysis. PhD thesis, C U.

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    Supervisors

    SupervisorsEmail
    Dutta, Chitra

    Abstract

    Microbes are one of the earliest organisms inhabiting earth since times life has originatedon the surface of this planet about 3.5 billion years ago. During these 3.5 billion years, microbes have evolve in a way to adapt themselves to all possible environment, even to the most extreme and adverse ones – thanks to the process of molecular evolution. Any study on evolution of life will be incomprehensive without studying the molecular evolution of microbes - the vehicles of all major evolutionary processes till to this date. With the advent of nextgen sequencing technologies, microbial sequences are regularly coming up at a break neck speed and this, in turn, has boosted up the studies on molecular evolution in microbes from diverse lineages and of widely varying life-style. As revealed in these studies, the genome composition of microbes, especially of bacterial species, often bear the signatures not only of their phylogenetic positions, but also of their niches and/or life-styles. The genetic constitution of a bacterium normally reflects a complex interplay between its taxonomic legacy and ecological constraints. While the legacy of the ancestral genetic trends is, by and large, followed within a specific lineage, adaptation to distinct niches or life-styles may cause fine-tuned variations in gene/protein composition across its members, even across the strains of a single species. In an attempt to probe into the process of such fine-tuned optimization between the taxonomic legacy and ecological adaptation, the present study was designed to focus on molecular evolution in a specific bacterial lineage – the Firmicutes with a special reference to its genera Bacillus

    Item Type: Thesis (PhD)
    URI: http://www.eprints.iicb.res.in/id/eprint/2661
    Subjects: Structural Biology & Bioinformatics
    Divisions: Indian Institute of Chemical Biology
    Depositing User: Ms Sutapa Ganguly
    Date Deposited: 24 May 2017 13:28
    Last Modified: 24 May 2017 13:28
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