C11/C9 Helical Folding in ab Hybrid Peptides Containing 1-Aminocyclohexane acetic acid (b3,3-Ac6c)

Wani, Naiem Ahmad and Raghothama, Srinivasarao and Singh, Umesh Prasad and Rai, Rajkishor (2017) C11/C9 Helical Folding in ab Hybrid Peptides Containing 1-Aminocyclohexane acetic acid (b3,3-Ac6c). Chemistry-A EuropeanJournal, 23 (35). pp. 8364-8370.

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    Abstract

    The present study describes the solid-state conformation of ab hybrid peptides, Boc-Leu-b3,3-Ac6c-OH, P1; Boc-Leu-b3,3-Ac6c-Leu-b3,3-Ac6c-OMe, P2; and Boc-Leub 3,3-Ac6c-Leu-b3,3-Ac6c-Leu-OMe, P3. The dipeptide P1 adopts extended conformations, whereas tetrapeptide P2 and pentapeptide P3 favor a helical conformation stabilized by mixed types of C11/C9 intramolecular hydrogen bonds. In peptide P3, the amino group of b3,3-Ac6c(2) and b3,3-Ac6c(4) residues occupies axial orientation, whereas in P2 it occupies axial and equatorial orientations for residues b3,3-Ac6c(2) and b3,3-Ac6c(4), respectively. The self-assembly of P3 forms channels filled with solvent molecules that present interesting patterns.

    Item Type: Article
    URI: http://www.eprints.iicb.res.in/id/eprint/2710
    Subjects: Nonlinear Dynamics
    Divisions: Indian Institute of Chemical Biology
    Depositing User: Ms Sutapa Ganguly
    Date Deposited: 03 Aug 2017 15:37
    Last Modified: 03 Aug 2017 15:37
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