MAOA Promoter Polymorphism and Attention Deficit Hyperactivity Disorder (ADHD) in Indian Children

Das, Manali and Das Bhowmik, Aneek and Sinha, Swagata and Chattopadhyay, Anindita and Chaudhuri, Keya and Singh, Manoranjan and Mukhopadhyay, Kanchan (2006) MAOA Promoter Polymorphism and Attention Deficit Hyperactivity Disorder (ADHD) in Indian Children. American Journal of Medical Genetics, 141B (6). pp. 637-642.

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    Abstract

    Attention deficit hyperactivity disorder (ADHD) is a highly disabling, early onset childhood neurobehavioral disorder with a higher occurrence in boys as compared to girls. Pharmacological and molecular genetic studies have revealed the influence of dopaminergic and serotonergic systems in the etiology of the disorder. Monoamine oxidase A (MAOA) is a mitochondrial enzyme that regulates the dopaminergic signals in the presynaptic region. Polymorphism in the promoter region of theMAOAgene, which comprises of 30 bp repeats with repeat number varying between 2.5, 3.5, 4.5, and 5.5, has been shown to be associated with various neurobehavioral disorders including ADHD. This is the first study on Indian ADHD cases to validate an association between transmission of MAOA promoter polymorphism and risk of ADHD. We have analyzed the MAOA promoter polymorphism in a group of ADHD probands, their parents and ethnically matched controls by UNPHASED. Our findings indicate significant difference in the frequency of 3.5 repeat allele (P¼0.02) between cases and controls and preferential transmission of the short allele (3.5 repeat) from mothers to maleADHDprobands (P¼0.005). We conclude that the short 3.5 repeat allele of the MAOA-u VNTR is probably associated with ADHD in our population and could be the reason for making boys prone to ADHD as compared to girls.

    Item Type: Article
    URI: http://www.eprints.iicb.res.in/id/eprint/403
    Subjects: Molecular & Human Genetics
    Divisions: Indian Institute of Chemical Biology
    Depositing User: Mr Santanu Sadhukhan
    Date Deposited: 31 Oct 2011 17:35
    Last Modified: 31 Oct 2011 17:35
    Official URL: http://dx.doi.org/10.1002/ajmg.b.30385
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