Antidiabetic, Antioxidant and Antihyperlipidemic Status of Heliotropium zeylanicum Extract on Streptozotocin-Induced Diabetes in Rats

Murugesh, Kandasamy and Yeligar, Veerendra and Dash, Deepak Kumar and Sengupta, Pinaki and Maiti, Bhim Chandra and Maity, Tapan Kumar (2006) Antidiabetic, Antioxidant and Antihyperlipidemic Status of Heliotropium zeylanicum Extract on Streptozotocin-Induced Diabetes in Rats. Biol. Pharm. Bull, 29 (11). pp. 2202-2205.

[img]

PDF
Restricted to IICB Scientists only

Download (230Kb) | Request a copy

    Abstract

    The potential role of the methanolic extract of Heliotropium zeylanicum (BURM.F) LAMK (MEHZ) in the treatment of diabetes along with its antioxidant and antihyperlipidemic effects was studied in streptozotocin-induced diabetic rats. Oral administration of (MEHZ) 150 and 300 mg/kg/d for 14 d significantly decreased the blood glucose level and considerably increased the body weight, food intake, and liquid intake of diabetic-induced rats. MEHZ significantly decreased thiobarbituric acid reactive substances and significantly increased reduced glutathione, superoxide dismutase and catalase in streptozotocin-induced diabetic rats at the end of 14 d of treatment. The study also investigated the antihyperlipidemic potential of MEHZ. The results show that the active fraction of MEHZ is promising for development of a standardized phytomedicine for the treatment of diabetes mellitus.

    Item Type: Article
    URI: http://www.eprints.iicb.res.in/id/eprint/420
    Subjects: Chemistry
    Divisions: Indian Institute of Chemical Biology
    Depositing User: Mr Shyamal Nath
    Date Deposited: 01 Nov 2011 17:36
    Last Modified: 03 Feb 2012 12:40
    Official URL: htpp://dx.doi.org/10.1248/bpb.29.2202
    Links:

    Actions (login required)

    View Item