Genomic Instabilities in Squamous Cell Carcinoma of Head and Neck From the Indian Population

Chakrabarti, Susmita and Sengupta, Shiladitya Sengupta and Sengupta, Arunava and Basak, Saminendra Nath and Roy, Anup and Panda, Chinmay and Roychoudhury, Susanta (2006) Genomic Instabilities in Squamous Cell Carcinoma of Head and Neck From the Indian Population. Molecular Carcinogenesis, 45 (4). pp. 270-277.

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    Abstract

    Intrinsic genomic instability of an incipient tumor cell drives the development of cancer. In colorectal cancer, an inverse relationship between microsatellite instability (MIN) and chromosomal instability (CIN) has been reported. The relationship between MIN and CIN in head and neck squamous cell carcinoma (HNSCC) is uncertain. In the present study, we examined these two types of instabilities in HNSCC using microsatellite markers and arbitrary primed PCR (APPCR) technique. HNSCC tumors showed high frequency of MIN and loss of heterozygosity (LOH). We observed that, in contrast to colorectal tumors, the frequency of LOH increased with the increase in MIN. There was no significant difference between MIN� and MINþ groups of HNSCC tumors in the extent of overall genomic alterations; rather higher MINþ tumors exhibited higher incidence of deletion. Thus, in sporadic HNSCC, both MIN and CIN pathways operate simultaneously to drive tumor formation. � 2006 Wiley-Liss, Inc.

    Item Type: Article
    URI: http://www.eprints.iicb.res.in/id/eprint/431
    Subjects: Molecular & Human Genetics
    Divisions: Indian Institute of Chemical Biology
    Depositing User: Ms Sutapa Ganguly
    Date Deposited: 01 Nov 2011 13:57
    Last Modified: 03 Feb 2012 11:12
    Official URL: http://dx.doi.org/10.1002/mc.20178
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