Topoisomerases of kinetoplastid parasites: why so fascinating

Das, Benu Brata and Sengupta, Tanushri and Ganguly, Agneyo and Majumder, Hemanta K (2006) Topoisomerases of kinetoplastid parasites: why so fascinating. Molecular Microbiology, 62 (4). pp. 917-927.

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    Abstract

    DNA topoisomerases are the key enzymes involved in carrying out high precision DNA transactions inside the cells. However, they are detrimental to the cell when a wide variety of topoisomerase-targeted drugs generate cytotoxic lesions by trapping the enzymes in covalent complexes on the DNA. The discovery of unusual heterodimeric topoisomerase I in kinetoplastid family added a new twist in topoisomerase research related to evolution, functional conservation and their preferential sensitivity to Camptothecin. On the other hand, structural and mechanistic studies on kinetoplastid topoisomerase II delineate some distinguishing features that differentiate the parasitic enzyme from its prokaryotic and eukaryotic counterparts. This review summarizes the recent advances in research in kinetoplastid topoisomerases, their evolutionary significance and the death of the unicellular parasite Leishmania donovani induced by topoisomerase I inhibitor camptothecin

    Item Type: Article
    URI: http://www.eprints.iicb.res.in/id/eprint/432
    Subjects: Infectious Diseases and Immunology
    Divisions: Indian Institute of Chemical Biology
    Depositing User: Ms Sutapa Ganguly
    Date Deposited: 01 Nov 2011 14:31
    Last Modified: 03 Feb 2012 11:38
    Official URL: http://dx.doi.org/10.1111/j.1365-2958.2006.05428.x
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