Effects of Garlic Oil on Postmenopausal Osteoporosis using Ovariectomized Rats: Comparison with the Effects of Lovastatin and 17β -Estradiol

Mukherjee, M and Das, A. S and Das, D and Mukherjee, S and Mitra, S and Mitra, C (2006) Effects of Garlic Oil on Postmenopausal Osteoporosis using Ovariectomized Rats: Comparison with the Effects of Lovastatin and 17β -Estradiol. Phytotherapy Research, 20 (1). pp. 21-27.

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    Abstract

    The purpose of this study was to examine the antiosteoporosis effects of garlic oil in an ovariectomized (Ovx) rat model of osteoporosis and to compare its efficacy with lovastatin (a synthetic hypocholesterolemic drug) and 17β -estradiol (a potent antiosteoporotic agent). Animals were divided into five groups: sham-operated control, ovariectomized, ovariectomized supplemented with lovastatin, ovariectomized supplemented with garlic oil and ovariectomized supplemented with 17β -estradiol. In our study, the development of a high rate of bone turnover and osteoporosis in the ovariectomized animals were confirmed by significant alterations of serum alkaline phosphatase activity, serum tartrate-resistant acid phosphatase activity, urinary excretion of calcium, phosphate, hydroxyproline and urinary calcium to creatinine ratio, when compared with the shamoperated control group. Supplementation of these animals with either garlic oil or lovastatin or 17β -estradiol, in addition to their hypocholesterolemic effect, could counterbalance all these changes. The results revealed that all three compounds significantly protected the hypogonadal bone loss as reflected by higher bone densities and higher bone mineral contents than the ovariectomized group of animals. The results emphasize that, like 17β -estradiol, the hypocholesterolemic compounds garlic oil and lovastatin are also effective in suppressing bone loss owing to estrogen deficiency and their efficacy in the order of lower to higher is garlic < lovastatin < 17β -estradiol. Copyright © 2006 John Wiley & Sons, Ltd.

    Item Type: Article
    URI: http://www.eprints.iicb.res.in/id/eprint/467
    Subjects: Drug Development/Diagnostics & Biotechnology
    Divisions: Indian Institute of Chemical Biology
    Depositing User: Ms Sutapa Ganguly
    Date Deposited: 02 Nov 2011 10:58
    Last Modified: 03 Feb 2012 12:34
    Official URL: http://dx.doi.org/10.1002/ptr.1795
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