A Novel Approach for the One-Pot Synthesis of Linear and Angular Fused Quinazolinones

Maity, Arindam and Mondal, Shyamal and Paira, Rupankar and Hazra, Abhijit and Naskar, Subhendu and Sahu, Krishnendu B and Saha, Pritam and Banerjee, Sukdeb and Mondal, Nirup B (2011) A Novel Approach for the One-Pot Synthesis of Linear and Angular Fused Quinazolinones. Tetrahedron Letters, 52 (23). pp. 3033-3037. ISSN 00404039

[img]

PDF
Restricted to IICB Scientists only

Download (523Kb) | Request a copy

    Abstract

    A convenient and inexpensive one step methodology has been developed for the synthesis of linear and angular fused quinazolinones. The protocol, which uses amino heterocycles and o-bromo benzyl/naphthyl bromides as reactants, CuI as catalyst, Cs2CO3 as base, L-proline as ligand, and DMF as solvent, proceeds via nucleophilic aromatic substitution of the N-heteroaromatic cationic intermediate followed by in situ aerial oxidation at the benzylic position to the quinazolinone scaffold.

    Item Type: Article
    URI: http://www.eprints.iicb.res.in/id/eprint/473
    Subjects: Chemistry
    Divisions: Indian Institute of Chemical Biology
    Depositing User: Hazra Abhijit Apu
    Date Deposited: 02 Nov 2011 14:01
    Last Modified: 31 Jan 2012 15:42
    Official URL: http://dx.doi.org/10.1016/j.tetlet.2011.04.019
    Links:

    Actions (login required)

    View Item