Functional Delivery of a Cytosolic tRNA into Mutant Mitochondria of Human Cells

Mahata, Bidesh and Mukherjee, Saikat and Mishra, Sumita and Bandyopadhyay, Arun and Adhya, Samit (2006) Functional Delivery of a Cytosolic tRNA into Mutant Mitochondria of Human Cells. Science, 314 (5798). pp. 471-474.

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    Abstract

    Many maternally inherited and incurable neuromyopathies are caused by mutations in mitochondrial (mt) transfer RNA (tRNA) genes. Kinetoplastid protozoa, including Leishmania, have evolved specialized systems for importing nucleus-encoded tRNAs into mitochondria. We found that the Leishmania RNA import complex (RIC) could enter human cells by a caveolin-1–dependent pathway, where it induced import of endogenous cytosolic tRNAs, including tRNALys, and restored mitochondrial function in a cybrid harboring a mutant mt tRNALys (MT-TK) gene. The use of protein complexes to modulate mitochondrial function may help in the management of such genetic disorders.

    Item Type: Article
    URI: http://www.eprints.iicb.res.in/id/eprint/489
    Subjects: Molecular & Human Genetics
    Divisions: Indian Institute of Chemical Biology
    Depositing User: Ms Sutapa Ganguly
    Date Deposited: 02 Nov 2011 13:14
    Last Modified: 07 Apr 2016 12:10
    Official URL: http://dx.doi.org/10.1126/science.1130276
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