Immunobiology of Granulocyte Macrophage Colony Stimulating Factor Driven Human Myeloid Cells

Ganguly, Dipyaman (2006) Immunobiology of Granulocyte Macrophage Colony Stimulating Factor Driven Human Myeloid Cells. PhD thesis, West Bengal University of Technology.

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    Supervisors

    SupervisorsEmail
    Bandyopadhyay, Santu

    Abstract

    Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) is well known to have growth-promoting activities on hematopoietic cell lineages. GM-CSF is known to stimulate multipotent progenitors depending on its concentration. Both in human and mouse, it was cloned from cDNA library of activated T lymphocytes. Various subsets of T lymphocytes have been found to produce GM-CSF on activation, although its direct effect on the T lymphocytes is not yet very clear. Most of the demonstrated effects of GM-CSF are believed to be mediated by the antigen presenting cells. Therapeutic uses of GMCSF, like G-CSF (Granulocyte Colony Stimulatory Factor), mainly involve treating neutropenia of different etiologies. Specifically, for treating chemotherapy-induced neutropenia and for expansion of hematopoietic progenitors prior to autologous transplantation, GMCSF and G-CSF have been in extensive use. Although they surely have growth-promoting activity on multi-lineage hematopoietic cells, possibilities are there that they also might have some immunomodulatory activities brought about by differential effects on different immune cells.

    Item Type: Thesis (PhD)
    URI: http://www.eprints.iicb.res.in/id/eprint/614
    Subjects: Infectious Diseases and Immunology
    Divisions: Indian Institute of Chemical Biology
    Depositing User: Mr Santanu Sadhukhan
    Date Deposited: 17 Nov 2011 16:23
    Last Modified: 17 Nov 2011 16:23
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