Manipulation of Signal Transduction Pathways of Chronic Myelogenous Leukemia Cells That Lead to Apoptosis

Rakshit, Srabanti (2006) Manipulation of Signal Transduction Pathways of Chronic Myelogenous Leukemia Cells That Lead to Apoptosis. PhD thesis, Jadavpur University.


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    Bandyopadhyay, Santu


    Leukemia was first described by European physicians during the mid-19th century. During autopsies, physicians noted cases of profoundly elevated white cell counts—today we know that many of these white cells were nonfunctional leukemic cells—and very low red cell counts. For this reason, the condition was referred to as weisses blut (German for “white blood”). Later, the term leukemia (Greek leukos, “white”; haima, “blood”) was applied to the disease (5). Leukemia or leukaemia starts when an immature blood cell in the bone marrow, known as a progenitor cell, becomes cancerous, dividing uncontrollably and overriding the body’s normal restrictions on cell division. Over time, the marrow becomes crowded with cancerous cells, all of them descendants of the first abnormal cell and devoid of normal healthy blood cells. The malignant cells may also accumulate in a patient’s lymph nodes, spleen, and elsewhere. At the time of diagnosis, up to a trillion leukemic cells may be present in the body. Thus, leukemia is a cancer of the blood or bone marrow characterized by an abnormal proliferation of blood cells, usually white blood cells (leukocytes). It is part of the broad group of diseases called hematological neoplasms.According to the American Cancer Society, leukemia is the sixth leading cause of cancer deaths among men and the seventh leading cause of cancer deaths among women. Each year in the United States about 31,000 new cases of leukemia are diagnosed and the disease causes an estimated 22,000 deaths. It accounts for about onethird of all cancers in children under age 15.

    Item Type: Thesis (PhD)
    Subjects: Infectious Diseases and Immunology
    Divisions: Indian Institute of Chemical Biology
    Depositing User: Mr Santanu Sadhukhan
    Date Deposited: 15 Nov 2011 10:43
    Last Modified: 31 Dec 2012 15:26

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