A Rapid and Facile Method for the General Synthesis of 3-Aryl Substituted 4,5,6,7-Tetrahydro[1,2,3]Triazolo[1,5-a]Pyrazines and their Ring Fused analogues

Chowdhury, Chinmay and Mukherjee, Sanjukta and Chakraborty, Biswajit and Achari, Basudeb (2011) A Rapid and Facile Method for the General Synthesis of 3-Aryl Substituted 4,5,6,7-Tetrahydro[1,2,3]Triazolo[1,5-a]Pyrazines and their Ring Fused analogues. Organic & Biomolecular Chemistry, 9 (16). pp. 5856-5862.

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    Abstract

    We report a general and facile method that provides rapid entry into 3-aryl substituted 4,5,6,7-tetrahydro[1,2,3]triazolo[1,5-a]pyrazines and their ring fused analogues in one-pot under palladium–copper catalysis. The methodology utilises simple and easily available substrates of broad range. The applicability of this reaction for the synthesis of optically active products has been demonstrated. A plausible reaction mechanism has also been proposed.

    Item Type: Article
    URI: http://www.eprints.iicb.res.in/id/eprint/66
    Subjects: Chemistry
    Divisions: Indian Institute of Chemical Biology
    Depositing User: Mr Shyamal Nath
    Date Deposited: 28 Sep 2011 19:40
    Last Modified: 27 Jan 2012 12:32
    Official URL: http://dx.doi.org/10.1039/c1ob05255a
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