A Modified Synthetic Approach to Optically Pure Benzoxazepines from Amino Acid Precursors Using Intramolecular Buchwald–Hartwig C–O Bond-Formation Reaction

Bhattacharya, Debleena and Behera, Ashok and Hota, Sandip K and Chattopadhyay, Partha (2011) A Modified Synthetic Approach to Optically Pure Benzoxazepines from Amino Acid Precursors Using Intramolecular Buchwald–Hartwig C–O Bond-Formation Reaction. SYNTHESIS (4). pp. 585-592.

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    Abstract

    Palladium-catalyzed intramolecular aryl etherification reaction using bulky binaphthylphosphane ligand is shown to be a convenient method for the synthesis of seven-membered heterocycles. Application of this methodology to a naturally occurring proteinogenic L-amino acid has led to the synthesis of optically active benzoxazepine ring systems of versatile biological importance

    Item Type: Article
    URI: http://www.eprints.iicb.res.in/id/eprint/83
    Subjects: Chemistry
    Divisions: Indian Institute of Chemical Biology
    Depositing User: Mr Shyamal Nath
    Date Deposited: 28 Sep 2011 19:38
    Last Modified: 31 Jan 2012 15:24
    Official URL: http://dx.doi.org/10.1055/s-0030-1258406
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